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Description for Protein RASA1

RAS p21 protein activator (GTPase activating protein) 1
66 total interacting proteins; 42 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/0)
(platelet: 7; secretome: 3)
Summary:
The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SH2: Src homology 2 domains
  • SH3: Src homology 3 domains
  • PH: Pleckstrin homology domain.
  • C2: Protein kinase C conserved region 2 (CalB)
  • RASGAP: GTPase-activator protein for Ras-like GTPases
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04352
    KEGG - Pathway(s):
    hsa04010; hsa04360
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Guanosine triphosphatase activating protein; GTPase activating protein; GAP; RAS p21 protein activator 1; p120GAP; RAS p21 protein activator 1 isoform 2; RAS p21 protein activator 1 isoform 1
    Approved Symbol:
    RASA1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 9
    Human (de-) phosphorylation sites: 9; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Basal cell carcinoma, somatic(Pd);
  • Capillary malformation-arteriovenous malformation(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00745 Entrez Gene ID: 5921 OMIM ID: 139150 Swissprot Accession: P20936;