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Description for Protein RARG

retinoic acid receptor, gamma
21 total interacting proteins; 11 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 1)
Summary:
Retinoic acid receptors (RARs), such as RARG, are nuclear hormone receptors that act as ligand-dependent transcriptional regulators. In their liganded state, RARs activate transcription, whereas in their nonliganded form, they repress transcription of their target genes. RARs have numerous target genes, which have retinoic response elements in their promoter regions (summary by Walkley et al., 2007 [PubMed 17574023]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • HOLI: Ligand binding domain of hormone receptors
  • ZnF_C4: c4 zinc finger in nuclear hormone receptors
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08529
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    RAR gamma 1; RARC; NR1B3; Retinoic acid receptor gamma isoform 1; Retinoic acid receptor gamma isoform 2
    Approved Symbol:
    RARG
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 3-FLUORO-4-[2-HYDROXY-2-(5,5,8,8-TETRAMETHYL-5,6,7,8,-TETRAHYDRO-NAPHTALEN-2-YL)-ACETYLAMINO]-BENZOIC ACID(db);
  • 4-[3-Oxo-3-(5,5,8,8-Tetramethyl-5,6,7,8-Tetrahydro-Naphthalen-2-Yl)-Propenyl]-Benzoic Acid(db);
  • Acitretin(db);
  • Adapalene(db);
  • Alitretinoin(db);
  • BMS184394(db);
  • CD564(db);
  • Dodecyl-Alpha-D-Maltoside(db);
  • Etretinate(db);
  • R-3-FLUORO-4-[2-HYDROXY-2-(5,5,8,8-TETRAMETHYL-5,6,7,8,-TETRAHYDRO-NAPHTALEN-2-YL)-ACETYLAMINO]-BENZOIC ACID(db);
  • SR11254(db);
  • Tazarotene(db);
  • Tretinoin(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01573 Entrez Gene ID: 5916 OMIM ID: 180190 Swissprot Accession: A8K3H3; P13631;