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Description for Protein RARB

retinoic acid receptor, beta
19 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. The gene expresses at least two transcript variants; one additional transcript has been described, but its full length nature has not been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • HOLI: Ligand binding domain of hormone receptors
  • ZnF_C4: c4 zinc finger in nuclear hormone receptors
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08528
    KEGG - Pathway(s):
    hsa05200; hsa05222; hsa05223
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    HAP; NR1B2; RRB2; RAR beta; Hepatitis B virus activated protein; RAR epsilon; Retinoic acid receptor beta 2; Retinoic acid receptor beta 4; HBV-activated protein; Retinoic acid receptor beta 5; Retinoic acid receptor, beta polypeptide; Retinoic acid receptor, beta isoform 1; Retinoic acid receptor, beta isoform 2
    Approved Symbol:
    RARB
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Acitretin(db);
  • Adapalene(db);
  • Alitretinoin(db);
  • Etretinate(db);
  • Tamibarotene(db);
  • Tazarotene(db);
  • TTNPB(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 07183 Entrez Gene ID: 5915 OMIM ID: 180220 Swissprot Accession: Q5QHG3; P10826;