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Description for Protein RARA

retinoic acid receptor, alpha
76 total interacting proteins; 26 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus. (PubMed Links)
Domains and Motifs:
  • HOLI: Ligand binding domain of hormone receptors
  • ZnF_C4: c4 zinc finger in nuclear hormone receptors
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08527
    KEGG - Pathway(s):
    hsa05200; hsa05221
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    RAR alpha form; NR1B1; RAR; Nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form; Retinoic acid receptor, alpha isoform a; Retinoic acid receptor, alpha isoform b
    Approved Symbol:
    RARA
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 19
    Human (de-) phosphorylation sites: 19; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Acitretin(db);
  • Adapalene(db);
  • Alitretinoin(db);
  • Etretinate(db);
  • Isotretinoin(db);
  • Tamibarotene(db);
  • Tazarotene(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06769 Entrez Gene ID: 5914 OMIM ID: 180240 Swissprot Accession: A8K840; P10276; B8Y636;