Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein RAP1A

RAP1A, member of RAS oncogene family
45 total interacting proteins; 21 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 7/1)
(membrane: 2; platelet: 6; undefined: 1)
Summary:
The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RAS: Ras subfamily of RAS small GTPases
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04353
    KEGG - Pathway(s):
    hsa04010; hsa04062; hsa04510; hsa04670; hsa04720; hsa04722; hsa05211
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    KREV1; C21KG; KREV-1 protein; SMGP21; RAP1; OTTHUMP00000059089; RAS-related protein RAP1A; Ras-related protein Krev-1; GTP-binding protein smg-p21A; G-22K; RAP1A, member of RAS oncogene family
    Approved Symbol:
    RAP1A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01545 Entrez Gene ID: 5906 OMIM ID: 179520 Swissprot Accession: P62834; A8KAH9;