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Description for Protein RANBP2

RAN binding protein 2
33 total interacting proteins; 9 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • ZnF_RBZ: Zinc finger domain
  • TPR: Tetratricopeptide repeats
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12172
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    NUP358; RanBP2; Nuclear pore complex protein Nup358; Nucleoporin Nup358; 358 kDa nucleoporin; P270
    Approved Symbol:
    RANBP2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 132
    Human (de-) phosphorylation sites: 132; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03111 Entrez Gene ID: 5903 OMIM ID: 601181 Swissprot Accession: P49792;