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Description for Protein RALGDS

ral guanine nucleotide dissociation stimulator
22 total interacting proteins; 16 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes.[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • RasGEFN: Guanine nucleotide exchange factor for Ras-like GTPases
  • N-terminal motif
  • RasGEF: Guanine nucleotide exchange factor for Ras-like small GTPases
  • RA: Ras association (RalGDS/AF-6) domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08732
    KEGG - Pathway(s):
    hsa05200; hsa05210; hsa05212
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    RalGEF; RGF; Ral guanine nucleotide dissociation stimulator isoform 1; Ral guanine nucleotide dissociation stimulator isoform 2
    Approved Symbol:
    RALGDS
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03371 Entrez Gene ID: 5900 OMIM ID: 601619 Swissprot Accession: Q8N4Y1; Q12967; Q6KH11;