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Description for Protein BCHE

butyrylcholinesterase
2 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. In the absence of the relaxant, the homozygote is at no known disadvantage. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.1.8
    KEGG - Orthology:
    K01050
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Pseudocholinesterase E1; CHE1; Acylcholine acylhydrolase; Choline esterase II; EC 3.1.1.8
    Approved Symbol:
    BCHE
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (1R)-MENTHYL HEXYL PHOSPHONATE GROUP(db);
  • (1S)-MENTHYL HEXYL PHOSPHONATE GROUP(db);
  • 2-(N-Morpholino)-Ethanesulfonic Acid(db);
  • 9-(3-IODOBENZYLAMINO)-1,2,3,4-TETRAHYDROACRIDINE(db);
  • 9-N-Phenylmethylamino-Tacrine(db);
  • Alpha-D-Mannose(db);
  • Beta-D-Mannose(db);
  • Butanoic Acid(db);
  • Butyrylthiocholine(db);
  • Choline(db);
  • Demecarium(db);
  • Diethylphosphono Group(db);
  • Dipivefrin(db);
  • DODECANESULFONATE ION(db);
  • Echothiophate(db);
  • Ethyl Dihydrogen Phosphate(db);
  • ETHYL HYDROGEN DIETHYLAMIDOPHOSPHATE(db);
  • Fucose(db);
  • Hexafluronium(db);
  • Isoflurophate(db);
  • Malathion(db);
  • Methyl Phosphinic Acid(db);
  • Monoisopropyl Ester Phosphonic Acid Group(db);
  • Rivastigmine(db);
  • Tacrine(db)

    Associated Genetic Diseases:

  • Apnea, postanesthetic, due to BCHE, atypical-1(Pd);
  • BCHE Cynthiana(Pd);
  • BCHE johannesburg(Pd);
  • BCHE Newfoundland(Pd);
  • BCHE, fluoride 1(Pd);
  • BCHE, fluoride 2(Pd);
  • BCHE, H variant(Pd);
  • BCHE, J variant(Pd);
  • BCHE, K variant(Pd);
  • BCHE, silent 1(Pd);
  • Butyrylcholinesterase deficiency(Pd);
  • Butyrylcholinesterase deficiency, fluoride-resistant, Japanese type(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 2
    • Additional Identifiers:

    HPRD: 01519 Entrez Gene ID: 590 OMIM ID: 177400 Swissprot Accession: P06276;