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Description for Protein RAF1

v-raf-1 murine leukemia viral oncogene homolog 1
116 total interacting proteins; 70 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • C1: Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • RBD: Raf-like Ras-binding domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K04366
    KEGG - Pathway(s):
    hsa04010; hsa04012; hsa04062; hsa04270; hsa04370; hsa04510; hsa04540; hsa04650; hsa04660; hsa04662; hsa04664; hsa04666; hsa04720; hsa04722; hsa04730; hsa04810; hsa04910; hsa04912; hsa04914; hsa04916; hsa05200; hsa05210; hsa05211; hsa05212; hsa05213; hsa05214; hsa05215; hsa05218; hsa05219; hsa05220; hsa05221; hsa05223
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Oncogene RAF1; Oncogene MIL; Raf-1; v-raf-1 murine leukemia viral oncogene homolog 1; Raf proto-oncogene serine/threonine protein kinase; CRAF; c-Raf; EC 2.7.11.1
    Approved Symbol:
    RAF1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 38
    Human (de-) phosphorylation sites: 38; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 6
    Human phosphorylation targets: 6; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Sorafenib(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01265 Entrez Gene ID: 5894 OMIM ID: 164760 Swissprot Accession: P04049;