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Description for Protein RAD51

RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)
46 total interacting proteins; 10 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • AAA: ATPases associated with a variety of cellular activities
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04482
    KEGG - Pathway(s):
    hsa03440; hsa05200; hsa05212
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Recombination protein A; RECA; RAD51A; HRAD51; RAD51 homolog protein; RecA-like protein; DNA repair protein RAD51 homolog 1; HsT16930; HsRad51; RAD51 homolog protein isoform 1; RAD51 homolog protein isoform 2; BRCA1/BRCA2-containing complex, subunit 5
    Approved Symbol:
    RAD51
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Phosphoaminophosphonic Acid-Adenylate Ester(db)

    Associated Genetic Diseases:

  • Breast cancer, familial(Pd);
  • Breast cancer, susceptibility to, in BRCA1 and BRCA2 carriers(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01557 Entrez Gene ID: 5888 OMIM ID: 179617 Swissprot Accession: B0FXP0; Q06609; Q6ZNA8;