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Description for Protein RAC1

ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
135 total interacting proteins; 65 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 8/0)
(alpha granules: 1; membrane: 2; microparticles: 1; platelet: 5)
Summary:
The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RHO: Rho (Ras homology) subfamily of Ras-like small GTPases
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04392
    KEGG - Pathway(s):
    hsa04010; hsa04062; hsa04310; hsa04360; hsa04370; hsa04510; hsa04520; hsa04620; hsa04650; hsa04662; hsa04664; hsa04666; hsa04670; hsa04722; hsa04810; hsa05014; hsa05100; hsa05120; hsa05131; hsa05200; hsa05210; hsa05211; hsa05212; hsa05416
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Ras-related C3 botulinum toxin substrate 1 isoform Rac1c; Ras like protein TC25; Rho family, small GTP binding protein RAC1; TC-25; p21-Rac1; Ras-related C3 botulinum toxin substrate 1 isoform Rac1; Ras-related C3 botulinum toxin substrate 1 isoform Rac1b
    Approved Symbol:
    RAC1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 9
    Human (de-) phosphorylation sites: 9; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Guanosine-5'-Diphosphate(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03627 Entrez Gene ID: 5879 OMIM ID: 602048 Swissprot Accession: P63000; A4D2P0; A4D2P1;