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Description for Protein MLL3

myeloid/lymphoid or mixed-lineage leukemia 3
10 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a nuclear protein with an AT hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain, a post-SET domain and a RING-type zinc finger. This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone methylation activity and is involved in transcriptional coactivation. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PHD: PHD zinc finger
  • HMG: high mobility group
  • CC: Coiled Coil
  • AT_hook: DNA binding domain with preference for A/T rich regions
  • FYRN: "FY-rich" domain, N-terminal region
  • FYRC: "FY-rich" domain, C-terminal region
  • SET: SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K09188
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Histone lysine N methyltransferase, H3 lysine 4 specific MLL3; Homologous to ALR protein; HALR; Myeloid/lymphoid or mixed-lineage leukemia 3 isoform 2; Myeloid/lymphoid or mixed-lineage leukemia 3 isoform 1
    Approved Symbol:
    MLL3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 45
    Human (de-) phosphorylation sites: 45; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06016 Entrez Gene ID: 58508 OMIM ID: 606833 Swissprot Accession: Q8NEZ4;