Summary:
This gene encodes a muscle enzyme involved in glycogenolysis. Highly similar enzymes encoded by different genes are found in liver and brain. Mutations in this gene are associated with McArdle disease (myophosphorylase deficiency), a glycogen storage disease of muscle. Alternative splicing results in multiple transcript variants. (PubMed Links)
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| Domains and Motifs:
Gene Ontology:
KEGG - Enzyme ID(s):
KEGG - Orthology:
K00688
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KEGG - Pathway(s):
hsa00500; hsa04910
(The yellow boxes represents platelet proteins) |
Nomenclature / Alternative Names:
Muscle glycogen phosphorylase; Glycogen phosphorylase, muscle form; M-GP; MGP; Phos; EC 2.4.1.1; Myophosphorylase
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Approved Symbol:
| (De-) Phosphorylations:
Phosphorylation Targets:
| Total phosphorylation targets: 0 |
| Human phosphorylation targets: 0; | Predicted platelet targets: 0 |
| Protein Characteristics:
|  Associated Drugs (DrugBank Accession):
(2S)-N-[(3S)-1-(2-AMINO-2-OXOETHYL)-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL]-2-CHLORO-2H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE(db);
(3,4,5-Trihydroxy-6-Hydroxymethyl-Tetrahydro-Pyran-2-Yl)-Phosphoramidic Acid Dimethyl Ester(db);
(3R,4R,5R)-5-(HYDROXYMETHYL)-1-(3-PHENYLPROPYL)PIPERIDINE-3,4-DIOL(db);
(3S,5R,7R,8S,9S,10R)-7-(hydroxymethyl)-3-(2-naphthyl)-1,6-dioxa-2-azaspiro[4.5]decane-8,9,10-triol(db);
(3S,5R,7R,8S,9S,10R)-7-(hydroxymethyl)-3-(4-methylphenyl)-1,6-dioxa-2-azaspiro[4.5]decane-8,9,10-triol(db);
(5R,7R,8S,9S,10R)-7-(hydroxymethyl)-3-phenyl-1,6-dioxa-2-azaspiro[4.5]dec-2-ene-8,9,10-triol(db);
(S)-2-CHLORO-N-(1-(2-(2-HYDROXYETHYLAMINO)-2-OXOETHYL)-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL)-6H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE(db);
({[(3E)-2'-OXO-2',7'-DIHYDRO-2,3'-BIINDOL-3(7H)-YLIDENE]AMINO}OXY)ACETIC ACID(db);
1-Deoxy-1-Acetylamino-Beta-D-Gluco-2-Heptulopyranosonamide(db);
1-Deoxy-1-Methoxycarbamido-Beta-D-Gluco-2-Heptulopyranosonamide(db);
1-Deoxy-1-Methoxycarbamido-Beta-D-Glucopyranose(db);
1-N-Acetyl-Beta-D-Glucosamine(db);
2,3-Dicarboxy-4-(2-Chloro-Phenyl)-1-Ethyl-5-Isopropoxycarbonyl-6-Methyl-Pyridinium(db);
2-(Beta-D-Glucopyranosyl)-5-Methyl-1,2,3-Benzimidazole(db);
2-(Beta-D-Glucopyranosyl)-5-Methyl-1,3,4-Benzothiazole(db);
2-(Beta-D-Glucopyranosyl)-5-Methyl-1,3,4-Oxadiazole(db);
2-CHLORO-N-[(1R,2R)-1-HYDROXY-2,3-DIHYDRO-1H-INDEN-2-YL]-6H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE(db);
2-CHLORO-N-[(3R)-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL]-6H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE(db);
2-DEOXY-3,4-BIS-O-[3-(4-HYDROXYPHENYL)PROPANOYL]-L-THREO-PENTARIC ACID(db);
2-Deoxy-Glucose-6-Phosphate(db);
3,8,9,10-Tetrahydroxy-7-Hydroxymethyl-6-Oxa-1,3-Diaza-Spiro[4.5]Decane-2,4-Dione(db);
3-Amino-8,9,10-Trihydroxy-7-Hydroxymethyl-6-Oxa-1,3-Diaza-Spiro[4.5]Decane-2,4-Dione(db);
4-{2,4-Bis[(3-Nitrobenzoyl)Amino]Phenoxy}Phthalic Acid(db);
4-{2-[(3-Nitrobenzoyl)Amino]Phenoxy}Phthalic Acid(db);
4-{3-CHLORO-4-[3-(2,4-DICHLORO-BENZOYL)-UREIDO]-PHENOXY}-BUTYRIC ACID(db);
4-{4-[3-(2,4-DICHLORO-BENZOYL)-UREIDO]-2,3-DIMETHYL-PHENOXY}-BUTYRIC ACID(db);
5-Chloro-1h-Indole-2-Carboxylic Acid [1-(4-Fluorobenzyl)-2-(4-Hydroxypiperidin-1yl)-2-Oxoethyl]Amide(db);
5-{3-[3-(2,4-DICHLORO-BENZOYL)-UREIDO]-2-METHYL-PHENOXY}-PENTANOIC ACID(db);
7-{2,6-DICHLORO-4-[3-(2-CHLORO-BENZOYL)-UREIDO]-PHENOXY}-HEPTANOIC ACID(db);
8,9,10-Trihydroxy-7-Hydroxymethyl-2-Thioxo-6-Oxa-1,3-Diaza-Spiro[4.5]Decan-4-One(db);
8,9,10-Trihydroxy-7-Hydroxymethyl-3-Methyl-6-Oxa-1,3-Diaza-Spiro[4.5]Decane-2,4-Dione(db);
Alpha-D-Glucopyranosyl-2-Carboxylic Acid Amide(db);
Alpha-D-Glucose-1-Phosphate(db);
Alpha-D-Glucose-6-Phosphate(db);
Beta-D-Glucopyranose Spirohydantoin(db);
Beta-D-Glucose(db);
C-(1-Azido-Alpha-D-Glucopyranosyl) Formamide(db);
C-(1-Hydrogyl-Beta-D-Glucopyranosyl) Formamide(db);
Flavopiridol(db);
Fluoro-Phosphite Ion(db);
Heptulose-2-Phosphate(db);
Indirubin-5-Sulphonate(db);
Inosinic Acid(db);
N'-Pyridoxyl-Lysine-5'-Monophosphate(db);
N-(8,9,10-Trihydroxy-7-Hydroxymethyl-2,4-Dioxo-6-Oxa-1,3-Diaza-Spiro[4.5]Dec-3-Yl-Acetamide(db);
N-Acetyl-N'-Beta-D-Glucopyranosyl Urea(db);
N-Benzoyl-N'-Beta-D-Glucopyranosyl Urea(db);
Nojirimycine Tetrazole(db);
Phosphonoserine(db);
Pyridoxal Phosphate(db)
Associated Genetic Diseases:
Mcardle disease(Pd)
| Predicted Transmembrane Domains:
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