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Description for Protein PVRL1

poliovirus receptor-related 1 (herpesvirus entry mediator C)
7 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • Ig_LIKE: Immunoglobulin like
  • TM: Transmembrane domain
  • IGV: Immunoglobulin V-Type
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06081
    KEGG - Pathway(s):
    hsa04514; hsa04520
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    HVEC; PRR; PRR1; PVRR1; SK 12; ED4; Nectin; CLPED1; CD111; Herpes virus entry mediator C; Herpesvirus Ig like receptor; HIgR; CD111 antigen; Poliovirus receptor like 1; Ectodermal dysplasia 4; Poliovirus receptor related; PVRR; HveC; Poliovirus receptor related 1 isoform 1; Poliovirus receptor related 1 isoform 2; Poliovirus receptor related 1 isoform 3; Poliovirus receptor related protein 1
    Approved Symbol:
    PVRL1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 7
    Human (de-) phosphorylation sites: 7; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Cleft lip/palate-ectodermal dysplasia syndrome(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 1
  • Isoform 2 : 2
  • Isoform 1 : 2
    • Additional Identifiers:

    HPRD: 07200 Entrez Gene ID: 5818 OMIM ID: 600644 Swissprot Accession: Q15223;