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Description for Protein RAD1

RAD1 homolog (S. pombe)
13 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • EXOIII: N-terminal domain in C. elegans NRF-6 (Nose Resistant to Fluoxetine-4) and NDG-4 (resistant to nordihydroguaiaretic acid-4).
  • LRR: Leucine-rich repeats, outliers
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.11.2
    KEGG - Orthology:
    K02830
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Rad1; Cell cycle checkpoint protein rad1 A/B; Rad1-like protein; DNA repair exonuclease REC1; DNA repair protein RAD1; Rad1-like DNA damage checkpoint protein; Cell cycle checkpoint protein HRAD1; DNA repair exonuclease; REC1; HRAD1; Rad1 like DNA damage checkpoint; Exonuclease homolog RAD1; RAD1 homolog isoform 1
    Approved Symbol:
    RAD1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04400 Entrez Gene ID: 5810 OMIM ID: 603153 Swissprot Accession: O60671;