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Description for Protein BAX

BCL2-associated X protein
38 total interacting proteins; 17 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 4/0)
(membrane: 1; platelet: 6)
Summary:
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • BCL: BCL (B-Cell lymphoma)
  • contains BH1, BH2 regions
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K02159
    KEGG - Pathway(s):
    hsa04115; hsa04210; hsa04722; hsa05014; hsa05016; hsa05020; hsa05200; hsa05210
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    BCL2-associated X protein isoform sigma; BCL2-associated X protein isoform epsilon; BCL2-associated X protein isoform delta; Apoptosis regulator BAX; BCL2 associated X protein; BCL2-associated X protein isoform beta
    Approved Symbol:
    BAX
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 14
    Human (de-) phosphorylation sites: 14; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Colorectal cancer(Pd);
  • Leukemia, T-cell acute lymphoblastic(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 6 : 1
  • Isoform 5 : 1
  • Isoform 4 : 1
  • Isoform 3 : 1
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02498 Entrez Gene ID: 581 OMIM ID: 600040 Swissprot Accession: Q07812; Q07814;