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Description for Protein PTS

6-pyruvoyltetrahydropterin synthase
8 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
The enzyme encoded by this gene catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
4.2.3.12
KEGG - Orthology:
K01737
KEGG - Pathway(s):
hsa00790; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
EC 4.2.3.12; PTPS; PTP synthase; 6 PTS
Approved Symbol:
PTS
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 3
Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Biopterin(db)

    Associated Genetic Diseases:

  • Hyperphenylalaninemia due to partial PTS deficiency(Pd);
  • Hyperphenylalaninemia due to PTS deficiency(Pd);
  • Hyperphenylalaninemia, transient(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 11840 Entrez Gene ID: 5805 OMIM ID: 612719 Swissprot Accession: Q03393;