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Description for Protein PTPRS

protein tyrosine phosphatase, receptor type, S
24 total interacting proteins; 9 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • FN3: Fibronectin type 3 domain
  • TM: Transmembrane domain
  • Tyr_Phos: Protein tyrosine phosphatase, catalytic domain
  • IGC2: Immunoglobulin C-2 Type
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.3.48
    KEGG - Orthology:
    K06778
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Phosphotyrosine phosphatase, receptor sigma; Protein tyrosine phosphatase LAR-PTP2; PTPase LAR-PTP2; Protein tyrosine phosphatase sigma; PTPase sigma; Protein tyrosine phosphatase PTPsigma; R-PTP sigma; PTP sigma; RPTPS; RPTP-sigma; CPTP1; PTP NE-3; Protein tyrosine phosphatase receptor type sigma isoform 2; Protein tyrosine phosphatase, receptor type, sigma isoform 4; Protein tyrosine phosphatase, receptor type, sigma isoform 3; Protein tyrosine phosphatase, receptor type, sigma isoform 1
    Approved Symbol:
    PTPRS
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 15
    Human (de-) phosphorylation sites: 15; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Alendronate(db);
  • Etidronic acid(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 2
  • Isoform 3 : 2
  • Isoform 2 : 2
  • Isoform 1 : 2
    • Additional Identifiers:

    HPRD: 03344 Entrez Gene ID: 5802 OMIM ID: 601576 Swissprot Accession: Q13332; Q8NHS7; Q2M3R7;