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Description for Protein PTPRO

protein tyrosine phosphatase, receptor type, O
3 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 3)
Summary:
This gene encodes a receptor-type protein tyrosine phosphatase containing a single intracellular catalytic domain with a characteristic signature motif. The gene product, which has a transmembrane domain, is an integral membrane protein. Several alternatively spliced transcript variants, some of which encode different isoforms of the protein, have been described. These variants exhibit tissue-specific expression. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • FN3: Fibronectin type 3 domain
  • TM: Transmembrane domain
  • Tyr_Phos: Protein tyrosine phosphatase, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.3.48
    KEGG - Orthology:
    K01104
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Glomerular epithelial protein 1; Receptor type protein tyrosine phosphatase O; Protein tyrosine phosphatase U2; Protein tyrosine phosphatase PTPU2; PTPase U2; GLEPP1; PTPU2; PTPROt; Phosphotyrosine phosphatase U2; Receptor-type protein tyrosine phosphatase O isoform a; Receptor-type protein tyrosine phosphatase O isoform b; Receptor-type protein tyrosine phosphatase O isoform c; Receptor-type protein tyrosine phosphatase O isoform d; EC 3.1.3.48
    Approved Symbol:
    PTPRO
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 6 : 2
  • Isoform 5 : 1
  • Isoform 4 : 2
  • Isoform 3 : 1
  • Isoform 2 : 1
  • Isoform 1 : 2
    • Additional Identifiers:

    HPRD: 02784 Entrez Gene ID: 5800 OMIM ID: 600579 Swissprot Accession: Q9UBT5; Q9UBF0; Q16827;