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Description for Protein PTPRN2

protein tyrosine phosphatase, receptor type, N polypeptide 2
3 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
  • Tyr_Phos: Protein tyrosine phosphatase, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.3.48
    KEGG - Orthology:
    K07817
    KEGG - Pathway(s):
    hsa04940
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    IAR; R-PTP-N2; ICAAR; Tyrosine phosphatase IA-2 beta; IAR/receptor like protein tyrosine phosphatase; Protein tyrosine phosphatase receptor-type N polypeptide 2; KIAA0387; Islet cell antigen related protein tyrosine phosphatase; PTPRP; IA-2beta; Receptor-type tyrosine-protein phosphatase N2; EC 3.1.3.48; Islet cell autoantigen related protein; Protein tyrosine phosphatase, receptor type, N polypeptide 2 isoform 1 precursor; Protein tyrosine phosphatase, receptor type, N polypeptide 2 isoform 2 precursor; Protein tyrosine phosphatase, receptor type, N polypeptide 2 isoform 3 precursor; Phogrin
    Approved Symbol:
    PTPRN2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 14
    Human (de-) phosphorylation sites: 14; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03413 Entrez Gene ID: 5799 OMIM ID: 601698 Swissprot Accession: Q92932; Q9Y4I6;