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Description for Protein PTPRM

protein tyrosine phosphatase, receptor type, M
10 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • Tyr_Phos: Protein tyrosine phosphatase, catalytic domain
  • IG: Immunoglobulin
  • MAM: Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
  • FN3: Fibronectin type 3 domain
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.3.48
    KEGG - Orthology:
    K05693
    KEGG - Pathway(s):
    hsa04514; hsa04520
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PTPRL1; Phosphotyrosine phosphatase receptor mu; RPTPmu; Protein tyrosine phosphatase receptor like 1; RPTPU; hR-PTPu; Protein tyrosine phosphatase mu
    Approved Symbol:
    PTPRM
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 7
    Human (de-) phosphorylation sites: 7; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 01479 Entrez Gene ID: 5797 OMIM ID: 176888 Swissprot Accession: A7MBN1; P28827;