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Description for Protein PTPRD

protein tyrosine phosphatase, receptor type, D
8 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • FN3: Fibronectin type 3 domain
  • TM: Transmembrane domain
  • Tyr_Phos: Protein tyrosine phosphatase, catalytic domain
  • IGC2: Immunoglobulin C-2 Type
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.3.48
    KEGG - Orthology:
    K06777
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Protein tyrosine phosphatase, receptor type, D isoform 1 precursor; Protein tyrosine phosphatase, receptor type, D isoform 3 precursor; Protein tyrosine phosphatase, receptor type, D isoform 2 precursor; Protein tyrosine phosphatase, receptor type, D isoform 4 precursor; Phosphotyrosine phosphatase, receptor, delta; RPTP delta; Protein tyrosine phosphatase, receptor type, delta; Protein tyrosine phosphatase delta; HPTP delta; HPTPD; HPTP; PTPD; Protein tyrosine phosphatase, receptor type, D isoform 5
    Approved Symbol:
    PTPRD
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 14
    Human (de-) phosphorylation sites: 14; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 5 : 1
  • Isoform 4 : 1
  • Isoform 3 : 1
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 03358 Entrez Gene ID: 5789 OMIM ID: 601598 Swissprot Accession: Q2HXI4; P23468; Q3KPJ1;