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Description for Protein PTPRC

protein tyrosine phosphatase, receptor type, C
49 total interacting proteins; 28 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(membrane: 1)
Summary:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • FN3: Fibronectin type 3 domain
  • TM: Transmembrane domain
  • Tyr_Phos: Protein tyrosine phosphatase, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.3.48
    KEGG - Orthology:
    K06478
    KEGG - Pathway(s):
    hsa04514; hsa04660; hsa04666; hsa05340
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Protein tyrosine phosphatase, receptor type, C isoform 2 precursor; Protein tyrosine phosphatase, receptor type, C isoform 3 precursor; Protein tyrosine phosphatase, receptor type, C isoform 4; Protein tyrosine phosphatase, receptor type, C isoform 1 precursor; CD45; Leukocyte common antigen; LCA; GP180; LY5; T200 glycoprotein; B220
    Approved Symbol:
    PTPRC
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 48
    Human (de-) phosphorylation sites: 48; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Multiple sclerosis, susceptibility to(Pd);
  • Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-positive(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 2
  • Isoform 2 : 2
  • Isoform 1 : 2
    • Additional Identifiers:

    HPRD: 01050 Entrez Gene ID: 5788 OMIM ID: 151460 Swissprot Accession: P08575; Q6PJK7; Q0VAE8;