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Description for Protein PTPRA

protein tyrosine phosphatase, receptor type, A
13 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/1)
(membrane: 1; platelet: 8)
Summary:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
  • Tyr_Phos: Protein tyrosine phosphatase, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.3.48
    KEGG - Orthology:
    K01104
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    EC 3.1.3.48; PTP alpha/PTPA LCA-related phosphatase; LRP; Protein tyrosine phosphatase alpha; R-PTP-alpha; PTPA; PTPase-alpha; HEPT; HLPR; HPTPA; HPTPalpha; PTPRL2; RPTPA; Leukocyte common antigen-related peptide; Tyrosine phosphatase alpha; PTPLCA-related phosphatase
    Approved Symbol:
    PTPRA
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 22
    Human (de-) phosphorylation sites: 22; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 2
  • Isoform 2 : 2
  • Isoform 1 : 2
    • Additional Identifiers:

    HPRD: 01476 Entrez Gene ID: 5786 OMIM ID: 176884 Swissprot Accession: P18433;