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Description for Protein PTPN14

protein tyrosine phosphatase, non-receptor type 14
7 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • B41: Band 4.1 homologues
  • Tyr_Phos: Protein tyrosine phosphatase, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.3.48
    KEGG - Orthology:
    K01104
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Protein tyrosine phosphatase pez; Phosphatase with ezrin domain; Pez; Cytoskeletal-associated protein tyrosine phosphatase; PTP36
    Approved Symbol:
    PTPN14
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 13
    Human (de-) phosphorylation sites: 13; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04402 Entrez Gene ID: 5784 OMIM ID: 603155 Swissprot Accession: Q6PJC3; Q15678;