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Description for Protein PTPN13

protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
20 total interacting proteins; 10 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PDZ: Domain present in PSD-95, Dlg, and ZO-1/2.
  • CC: Coiled Coil
  • Tyr_Phos: Protein tyrosine phosphatase, catalytic domain
  • LZ: Leucine Zipper
  • B41: Band 4.1 homologues
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K02374
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    FAP1; Protein tyrosine phosphatase 1E; PTP1E; PTPBAS; PNP1; PTPL1; PTPLE; PTP-BL; PTP-BAS; DKFZp686J1497; Fas associated phosphatase 1; Protein tyrosine phosphatase, non-receptor type 13 isoform 4; Protein tyrosine phosphatase, non-receptor type 13 isoform 3; Protein tyrosine phosphatase, non-receptor type 13 isoform 1; Protein tyrosine phosphatase, non-receptor type 13 isoform 2
    Approved Symbol:
    PTPN13
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 39
    Human (de-) phosphorylation sites: 39; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02602 Entrez Gene ID: 5783 OMIM ID: 600267 Swissprot Accession: Q12923;