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Description for Protein PTPN11

protein tyrosine phosphatase, non-receptor type 11
120 total interacting proteins; 64 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(microparticles: 1)
Summary:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SH2: Src homology 2 domains
  • Tyr_Phos: Protein tyrosine phosphatase, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.3.48
    KEGG - Orthology:
    K07293
    KEGG - Pathway(s):
    hsa04630; hsa04650; hsa04670; hsa04722; hsa04920; hsa05120; hsa05211; hsa05220
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    SHP2; CFC; NS1; BPTP3; MGC14433; SH-PTP2; SH-PTP3; EC 3.1.3.48; SHP-2; Shp2; SH2 containing protein tyrosine phosphatase 2; Protein tyrosine phosphatase 2C; PTP2C; Tyrosine phosphatase SHP2; PTP-1D; Syp
    Approved Symbol:
    PTPN11
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 16
    Human (de-) phosphorylation sites: 16; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 1
    Human phosphorylation targets: 1; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Dodecane-Trimethylamine(db)

    Associated Genetic Diseases:

  • Leopard syndrome(Pd);
  • Leukemia, juvenile myelomonocytic(Pd);
  • Noonan syndrome(Pd);
  • Noonan syndrome 1(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01470 Entrez Gene ID: 5781 OMIM ID: 176876 Swissprot Accession: Q06124;