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Description for Protein PTPN6

protein tyrosine phosphatase, non-receptor type 6
99 total interacting proteins; 42 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 8/0)
(membrane: 2; microparticles: 1; platelet: 4; secretome: 3)
Summary:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SH2: Src homology 2 domains
  • Tyr_Phos: Protein tyrosine phosphatase, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.3.48
    KEGG - Orthology:
    K05697
    KEGG - Pathway(s):
    hsa04520; hsa04630; hsa04650; hsa04660; hsa04662; hsa05140
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Protein tyrosine phosphatase, non-receptor type 6 isoform 2; SHP-1; SHP1; HPTP1C; SHP-1L; 70 kda SHP-1L protein; Hematopoietic cell protein-tyrosine phosphatase; Protein tyrosine phosphatase, non-receptor type 6 isoform 1; Protein tyrosine phosphatase 1C; Tyrosine phosphatase SHP1; SH2 containing protein tyrosine phosphatase 1; Hematopoietic cell phosphatase; PTP1C; HCPH; PTP-1C; SH-PTP1; HCP
    Approved Symbol:
    PTPN6
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 27
    Human (de-) phosphorylation sites: 27; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01475 Entrez Gene ID: 5777 OMIM ID: 176883 Swissprot Accession: P29350; Q9UK67; Q53XS4;