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Description for Protein TRIB3

tribbles homolog 3 (Drosophila)
26 total interacting proteins; 14 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.-
    KEGG - Orthology:
    K08814
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    NIPK; SINK; SKIP3; C20orf97; TRB3; Tribbles homolog 3; Chromosome 20 open reading frame 97; Neuronal cell death inducible putative kinase; p65 interacting inhibitor of NF kappaB
    Approved Symbol:
    TRIB3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09836 Entrez Gene ID: 57761 OMIM ID: 607898 Swissprot Accession: Q96RU7;