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Description for Protein SPTBN4

spectrin, beta, non-erythrocytic 4
5 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 3)
Summary:
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein localizes to the nuclear matrix, PML nuclear bodies, and cytoplasmic vesicles. A highly similar gene in the mouse is required for localization of specific membrane proteins in polarized regions of neurons. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SPECTRIN: Spectrin repeat
  • CH: Calponin homology domain
  • PH: Pleckstrin homology domain.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06115
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Spectrin, beta, non-erythrocytic 4 isoform 1; Spectrin, beta, non-erythrocytic 4 isoform 2; Spectrin, beta, non-erythrocytic 4; Spectrin beta chain, brain 3; Spectrin, non-erythroid beta chain 3; SPTBN3; KIAA1642; QV
    Approved Symbol:
    SPTBN4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09372 Entrez Gene ID: 57731 OMIM ID: 606214 Swissprot Accession: Q9H254; Q9H253;