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Description for Protein ARHGAP21

Rho GTPase activating protein 21
4 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • RHOGAP: GTPase-activator protein for Rho-like GTPases
  • PDZ: Domain present in PSD-95, Dlg, and ZO-1/2.
  • PH: Pleckstrin homology domain.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    ARHGAP10
    Approved Symbol:
    ARHGAP21
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 53
    Human (de-) phosphorylation sites: 53; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06445 Entrez Gene ID: 57584 OMIM ID: 609870 Swissprot Accession: Q5T5U3;