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Description for Protein TWF1

twinfilin, actin-binding protein, homolog 1 (Drosophila)
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(: 1; platelet: 3)
Summary:
This gene encodes twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • ADF: Actin depolymerisation factor/cofilin -like domains
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08870
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    A6; MGC23788; MGC41876; A6 protein tyrosine kinase; A6 protein; Twinfilin 1; Twinfilin isoform 1
    Approved Symbol:
    TWF1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 8
    Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 10174 Entrez Gene ID: 5756 OMIM ID: 610932 Swissprot Accession: Q12792;