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Description for Protein MTUS1

microtubule associated tumor suppressor 1
2 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Mitochondrial tumor suppressor 1 isoform 2; Mitochondrial tumor suppressor 1 isoform 3; Mitochondrial tumor suppressor 1 isoform 4; Mitochondrial tumor suppressor 1 isoform 5; Mitochondrial tumor suppressor 1 isoform 1; Transcription factor MTSG1; AT2 receptor interacting protein; Erythroid differentiation related gene; ATIP; MP44; MTSG1; FLJ14295; KIAA1288; DKFZp586D1519; DKFZp686F20243
    Approved Symbol:
    MTUS1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 29
    Human (de-) phosphorylation sites: 29; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 1
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 11376 Entrez Gene ID: 57509 OMIM ID: 609589 Swissprot Accession: Q9ULD2; B4DH03;