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Description for Protein NLN

neurolysin (metallopeptidase M3 family)
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13). The encoded protein is likely involved in the termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract. (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.24.16
    KEGG - Orthology:
    K01393
    KEGG - Pathway(s):
    hsa04614
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Mep; Neurotensin endopeptidase; Mitochondrial oligopeptidase M; Metallopeptidase M3 Family; Microsomal endopeptidase; Mop; Mitochondrial neurolysin; Soluble angiotensin II binding protein
    Approved Symbol:
    NLN
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 07495 Entrez Gene ID: 57486 OMIM ID: 611530 Swissprot Accession: Q9BYT8;