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Description for Protein PTK2

PTK2 protein tyrosine kinase 2
103 total interacting proteins; 65 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(platelet: 8; undefined: 1)
Summary:
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. At least four transcript variants encoding four different isoforms have been found for this gene, but the full-length natures of only two of them have been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • Tyr_Kinase: tyrosine kinase domain
  • B41: Band 4.1 homologues
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.10.2
    KEGG - Orthology:
    K05725
    KEGG - Pathway(s):
    hsa04012; hsa04062; hsa04360; hsa04370; hsa04510; hsa04670; hsa04810; hsa05100; hsa05200; hsa05222
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    FADK 1; Protein tyrosine kinase 2; pp125FAK; EC 2.7.1.112; Focal adhesion kinase 1; FAK1; PTK2 protein tyrosine kinase 2 isoform a; PTK2 protein tyrosine kinase 2 isoform b
    Approved Symbol:
    PTK2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 89
    Human (de-) phosphorylation sites: 89; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 10
    Human phosphorylation targets: 10; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2-({5-CHLORO-2-[(2-METHOXY-4-MORPHOLIN-4-YLPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)-N-METHYLBENZAMIDE(db);
  • 7-PYRIDIN-2-YL-N-(3,4,5-TRIMETHOXYPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-2-AMINE(db);
  • Adenosine-5'-Diphosphate(db);
  • N-(4-chlorobenzyl)-N',N'-dimethyl-N-pyridin-2-ylethane-1,2-diamine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02859 Entrez Gene ID: 5747 OMIM ID: 600758 Swissprot Accession: Q658W2; Q05397; Q8IYN9;