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Description for Protein PTGS2

prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
14 total interacting proteins; 12 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(platelet: 1; undefined: 1)
Summary:
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • EGF: Epidermal growth factor-like domain.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.14.99.1
    KEGG - Orthology:
    K11987
    KEGG - Pathway(s):
    hsa00590; hsa04370; hsa05140; hsa05200; hsa05222
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Prostaglandin endoperoxide synthase 2; COX2; Prostaglandin G/H synthase 2; PGHS2; Prostaglandin H2 synthase 2; PHS II
    Approved Symbol:
    PTGS2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1-Phenylsulfonamide-3-Trifluoromethyl-5-Parabromophenylpyrazole(db);
  • Acetaminophen(db);
  • Acetylsalicylic acid(db);
  • Aminosalicylic Acid(db);
  • Antipyrine(db);
  • Antrafenine(db);
  • B-Octylglucoside(db);
  • Balsalazide(db);
  • Bismuth Subsalicylate(db);
  • Bromfenac(db);
  • Carprofen(db);
  • Celecoxib(db);
  • Diclofenac(db);
  • Diflunisal(db);
  • Etodolac(db);
  • Etoricoxib(db);
  • Fenoprofen(db);
  • Flufenamic Acid(db);
  • Flurbiprofen(db);
  • gamma-Homolinolenic acid(db);
  • Ginseng(db);
  • Heme(db);
  • Ibuprofen(db);
  • Icosapent(db);
  • Indomethacin(db);
  • Ketoprofen(db);
  • Ketorolac(db);
  • Lenalidomide(db);
  • Lornoxicam(db);
  • Lumiracoxib(db);
  • Magnesium salicylate(db);
  • Meclofenamic acid(db);
  • Mefenamic acid(db);
  • Meloxicam(db);
  • Mesalazine(db);
  • Nabumetone(db);
  • Naproxen(db);
  • Nepafenac(db);
  • Niflumic Acid(db);
  • Nimesulide(db);
  • Oxaprozin(db);
  • Phenylbutazone(db);
  • Piroxicam(db);
  • Prostaglandin G2(db);
  • Resveratrol(db);
  • Rofecoxib(db);
  • Salicyclic acid(db);
  • Salicylate-sodium(db);
  • Salsalate(db);
  • Sulfasalazine(db);
  • Sulindac(db);
  • Suprofen(db);
  • Tenoxicam(db);
  • Thalidomide(db);
  • Tiaprofenic acid(db);
  • Tolmetin(db);
  • Trisalicylate-choline(db);
  • Valdecoxib(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02599 Entrez Gene ID: 5743 OMIM ID: 600262 Swissprot Accession: P35354;