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Description for Protein PTGS1

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
2 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 8/2)
(membrane: 2; microparticles: 1; platelet: 9; undefined: 1)
Summary:
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • EGF: Epidermal growth factor-like domain.
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.14.99.1
    KEGG - Orthology:
    K00509
    KEGG - Pathway(s):
    hsa00590; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PCOX1; Prostaglandin endoperoxide synthase 1; Prostaglandin g/h synthase 1; Cyclooxygenase 3; Prostaglandin H2 synthase 1; PGH synthase 1; PHS 1; COX1; PGHS1; COX3; PTGHS
    Approved Symbol:
    PTGS1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (3-Chloro-4-Propoxy-Phenyl)-Acetic Acid(db);
  • 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYL INDOLE-3-ACETIC ACID(db);
  • 2-(1,1'-Biphenyl-4-Yl)Propanoic Acid(db);
  • 2-Bromoacetyl Group(db);
  • 2-[1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOL-3-YL]-N-[(1R)-1-(HYDROXYMETHYL)PROPYL]ACETAMIDE(db);
  • 2-[1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOL-3-YL]-N-[(1S)-1-(HYDROXYMETHYL)PROPYL]ACETAMIDE(db);
  • Acetaminophen(db);
  • Acetic Acid Salicyloyl-Amino-Ester(db);
  • Acetylsalicylic acid(db);
  • Alpha-D-Mannose(db);
  • Antipyrine(db);
  • Antrafenine(db);
  • Arachidonic Acid(db);
  • B-Octylglucoside(db);
  • Balsalazide(db);
  • Beta-D-Glucose(db);
  • Beta-D-Mannose(db);
  • Bismuth Subsalicylate(db);
  • Bromfenac(db);
  • Carprofen(db);
  • Diclofenac(db);
  • Diethylcarbamazine(db);
  • Diflunisal(db);
  • Dipyrone(db);
  • Etodolac(db);
  • Fenoprofen(db);
  • Flufenamic Acid(db);
  • Flurbiprofen(db);
  • Flurbiprofen Methyl Ester(db);
  • gamma-Homolinolenic acid(db);
  • Heme(db);
  • Hyperforin(db);
  • Ibuprofen(db);
  • Icosapent(db);
  • Indomethacin(db);
  • Ketoprofen(db);
  • Ketorolac(db);
  • Lornoxicam(db);
  • Lumiracoxib(db);
  • Magnesium salicylate(db);
  • Meclofenamic acid(db);
  • Mefenamic acid(db);
  • Meloxicam(db);
  • Mesalazine(db);
  • Minoxidil(db);
  • Nabumetone(db);
  • Naproxen(db);
  • Nepafenac(db);
  • O-Acetylserine(db);
  • Oxaprozin(db);
  • P-(2'-Iodo-5'-Thenoyl)Hydrotropic Acid(db);
  • Phenacetin(db);
  • Phenylbutazone(db);
  • Piroxicam(db);
  • Protoporphyrin Ix Containing Co(db);
  • Resveratrol(db);
  • Salicyclic acid(db);
  • Salicylate-sodium(db);
  • Salsalate(db);
  • Sulfasalazine(db);
  • Sulindac(db);
  • Suprofen(db);
  • Tenoxicam(db);
  • Tiaprofenic acid(db);
  • Tolmetin(db);
  • Trisalicylate-choline(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 07518 Entrez Gene ID: 5742 OMIM ID: 176805 Swissprot Accession: P23219;