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Description for Protein PTGIR

prostaglandin I2 (prostacyclin) receptor (IP)
6 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(membrane: 1; undefined: 1)
Summary:
The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04263
    KEGG - Pathway(s):
    hsa04080; hsa04270
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Prostanoid IP receptor; PGI receptor; Prostaglandin I2 receptor; PRIPR; IP
    Approved Symbol:
    PTGIR
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Dinoprost Tromethamine(db);
  • Epoprostenol(db);
  • Iloprost(db);
  • Treprostinil(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 08959 Entrez Gene ID: 5739 OMIM ID: 600022 Swissprot Accession: P43119;