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Description for Protein PTGER3

prostaglandin E receptor 3 (subtype EP3)
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04260
    KEGG - Pathway(s):
    hsa04020; hsa04080
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Prostanoid EP3 receptor; PGE receptor EP3 subtype; Prostaglandin E2 receptor; Prostaglandin receptor PGE 2; Prostaglandin E2 receptor EP3 subtype; MGC27302; EP3; EP3e; PGE2-R; Prostaglandin E receptor 3, subtype EP3 isoform 1; Prostaglandin E receptor 3, subtype EP3 isoform 3; Prostaglandin E receptor 3, subtype EP3 isoform 2; Prostaglandin E receptor 3, subtype EP3 isoform 4; Prostaglandin E receptor 3, subtype EP3 isoform 5; Prostaglandin E receptor 3, subtype EP3 isoform 6; Prostaglandin E receptor 3, subtype EP3 isoform 7; Prostaglandin E receptor 3, subtype EP3 isoform 8
    Approved Symbol:
    PTGER3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Bimatoprost(db);
  • Dinoprostone(db);
  • Misoprostol(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
    08906_11(6)
    08906_10(6)
  • Isoform 9 : 6
  • Isoform 8 : 6
  • Isoform 7 : 6
  • Isoform 6 : 6
  • Isoform 5 : 6
  • Isoform 4 : 6
  • Isoform 3 : 6
  • Isoform 2 : 6
  • Isoform 1 : 6
    • Additional Identifiers:

    HPRD: 08906 Entrez Gene ID: 5733 OMIM ID: 176806 Swissprot Accession: P43115; O00325; B1AK19;