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Description for Protein PTGDS

prostaglandin D2 synthase 21kDa (brain)
9 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    5.3.99.2
    KEGG - Orthology:
    K01830
    KEGG - Pathway(s):
    hsa00590; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PDS; PGDS; PGDS2; Beta trace protein; Cerebrin 28; PGD2 synthase; Prostaglandin D synthase; Prostaglandin-H2 D-isomerase; Prostaglandin D2 synthase 21kDa; Glutathione-independent PGD synthase; Lipocalin-type prostaglandin D synthase; PGD2
    Approved Symbol:
    PTGDS
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 08904 Entrez Gene ID: 5730 OMIM ID: 176803 Swissprot Accession: P41222;