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Description for Protein PTEN

phosphatase and tensin homolog
36 total interacting proteins; 19 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 1)
Summary:
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • DSPC: Dual specificity phosphatase, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.3.67
    KEGG - Orthology:
    K01110
    KEGG - Pathway(s):
    hsa00562; hsa04070; hsa04115; hsa04510; hsa04530; hsa05200; hsa05213; hsa05214; hsa05215; hsa05218; hsa05222
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    MMAC1; Phosphatase and tensin homolog; Mutated in multiple advanced cancers 1; TEP1
    Approved Symbol:
    PTEN
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 18
    Human (de-) phosphorylation sites: 18; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Bannayan-Riley-Ruvalcaba syndrome(Pd);
  • Cowden disease(Pd);
  • Cowden syndrome(Pd);
  • Cowden syndrome-like phenotype(Pd);
  • Endometrial carcinoma(Pd);
  • Lhermitte-Duclos disease(Pd);
  • Macrocephaly/autism syndrome(Pd);
  • Malignant melanoma, somatic(Pd);
  • Oligodendroglioma(Pd);
  • Prostate cancer, somatic(Pd);
  • Proteus syndrome(Pd);
  • PTEN hamartoma tumor syndrome with granular cell tumor(Pd);
  • Squamous cell carcinoma, head and neck, somatic(Pd);
  • Vater association with hydrocephalus(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03431 Entrez Gene ID: 5728 OMIM ID: 601728 Swissprot Accession: P60484;