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Description for Protein PSPH

phosphoserine phosphatase
4 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene belongs to a subfamily of the phosphotransferases. This encoded enzyme is responsible for the third and last step in L-serine formation. It catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. Deficiency of this protein is thought to be linked to Williams syndrome. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
3.1.3.3
KEGG - Orthology:
K01079
KEGG - Pathway(s):
hsa00260; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
PSP; O-phosphoserine phosphohydrolase; PSPase; L-3-phosphoserine phosphatase
Approved Symbol:
PSPH
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 2
Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • D-2-Amino-3-Phosphono-Propionic Acid(db)

    Associated Genetic Diseases:

  • Phosphoserine phosphatase deficiency(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01406 Entrez Gene ID: 5723 OMIM ID: 172480 Swissprot Accession: P78330;