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Description for Protein PSME1

proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
11 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 6/0)
(platelet: 5; secretome: 2)
Summary:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Two transcripts encoding different isoforms have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06696
    KEGG - Pathway(s):
    hsa03050; hsa04612
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Proteasome activator 28 alpha; PA28 alpha; PA28A; Interferon gamma inducible protein 5111; IFI5111; Proteasome activator subunit 1; REGalpha; 11S regulator complex alpha subunit; 29-kD MCP activator subunit; multicatalytic protease subunit 1 activator; interferon-gamma IEF SSP 5111; interferon-gamma-inducible protein 5111; Interferon gamma up-regulated I-5111 protein; IGUP I-5111; MGC8628; Proteasome activator subunit 1 isoform 2; Proteasome activator subunit 1 isoform 1
    Approved Symbol:
    PSME1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02803 Entrez Gene ID: 5720 OMIM ID: 600654 Swissprot Accession: Q06323; Q86SZ9; Q6IBM2;