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Description for Protein BAD

BCL2-associated agonist of cell death
41 total interacting proteins; 26 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K02158
KEGG - Pathway(s):
hsa04012; hsa04210; hsa04370; hsa04510; hsa04722; hsa04910; hsa05010; hsa05014; hsa05200; hsa05210; hsa05212; hsa05213; hsa05215; hsa05218; hsa05220; hsa05221; hsa05223
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
BCL2 binding protein; BCL2L8; BCL2 binding component 6; Bcl-XL/Bcl-2 associated death promoter; BBC6; BBC2; BCL-X/BCL-2 binding protein
Approved Symbol:
BAD
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 16
Human (de-) phosphorylation sites: 16; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04409 Entrez Gene ID: 572 OMIM ID: 603167 Swissprot Accession: Q6FH21; Q92934;