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Description for Protein SMURF1

SMAD specific E3 ubiquitin protein ligase 1
85 total interacting proteins; 26 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. A similar protein in Xenopus is involved in embryonic pattern formation. Alternative splicing results in multiple transcript variants encoding different isoforms. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • C2: Protein kinase C conserved region 2 (CalB)
  • WW: Domain with 2 conserved Trp (W) residues
  • NES: Nuclear Export Signal
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    6.3.2.19
    KEGG - Orthology:
    K04678
    KEGG - Pathway(s):
    hsa04120; hsa04144; hsa04350
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    E3 ubiquitin ligase SMURF1; Ubiquitin protein ligase SMURF1; Smad ubiquitination regulatory factor 1 isoform 1; Smad ubiquitination regulatory factor 1 isoform 2; KIAA1625; EC 6.3.2.-; Smad ubiquitination regulatory factor 1
    Approved Symbol:
    SMURF1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06902 Entrez Gene ID: 57154 OMIM ID: 605568 Swissprot Accession: Q9HCE7; Q547Q3;