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Description for Protein RTN4

reticulon 4
26 total interacting proteins; 12 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 9/1)
(membrane: 2; microparticles: 1; platelet: 13)
Summary:
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    NSP; RTN-X; RTN4-A; RTN4-C; RTN4-B1; RTN4-B2; Nbla00271; Nbla10545; Neuroendocrine-specific protein; KIAA0886; SP1507; Reticulon 4 isoform A; Reticulon 4 isoform C; Reticulon 4 isoform B; Reticulon 4 isoform D; Reticulon 4 isoform E; Neurite outgrowth inhibitor; NOGO; NOGOA; NOGOB; NOGOC; Foocen; Neurite growth inhibitor 220; NI220; NI220/250; Neuroendocrine specific protein C homolog; Reticulon 5; My043 protein; ASY; NSP-CL
    Approved Symbol:
    RTN4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 38
    Human (de-) phosphorylation sites: 38; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 5 : 2
  • Isoform 4 : 2
  • Isoform 3 : 2
  • Isoform 2 : 2
  • Isoform 1 : 2
    • Additional Identifiers:

    HPRD: 07259 Entrez Gene ID: 57142 OMIM ID: 604475 Swissprot Accession: Q7L7Q6; Q7L7Q5; Q9NQC3;