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Description for Protein PSMD4

proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
27 total interacting proteins; 16 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(platelet: 6)
Summary:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • VWA: von Willebrand factor (vWF) type A domain
  • UIM: Ubiquitin-interacting motif.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03029
    KEGG - Pathway(s):
    hsa03050
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Protease 26S, subunit 5A; S5A; Rpn10; AF; ASF; MCB1; 26S protease subunit S5a; 26S proteasome regulatory subunit S5A; Antisecretory factor-1; Multiubiquitin chain binding protein; AF-1; pUB-R5; proteasome 26S non-ATPase subunit 4 isoform 2; Proteasome 26S non-ATPase subunit 4 isoform 1
    Approved Symbol:
    PSMD4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 10
    Human (de-) phosphorylation sites: 10; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03386 Entrez Gene ID: 5710 OMIM ID: 601648 Swissprot Accession: P55036;