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Description for Protein PSMB8

proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
4 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 4/1)
(microparticles: 1; platelet: 3; secretome: 3)
Summary:
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
3.4.25.1
KEGG - Orthology:
K02740
KEGG - Pathway(s):
hsa03050
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Large multifunctional protease 7; LMP7; Proteasome-related gene 7; RING10; Proteasome component C13; Proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7); D6S216; D6S216E; MGC1491; Proteasome beta 8 subunit; OTTHUMP00000062981; Macropain subunit C13; Proteasome subunit Y2; Proteasome subunit beta 5i; Low molecular weight protein 7; Proteasome catalytic subunit 3i; Y2; EC 3.4.25.1; Proteasome beta 8 subunit isoform E2 proprotein; Proteasome beta 8 subunit isoform E1 proprotein
Approved Symbol:
PSMB8
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 11
Human (de-) phosphorylation sites: 11; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01515 Entrez Gene ID: 5696 OMIM ID: 177046 Swissprot Accession: P28062; Q5QNR8;