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Description for Protein SPPL2B

signal peptide peptidase-like 2B
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
  • PSN: Presenilin, signal peptide peptidase, family
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.23.-
    KEGG - Orthology:
    K09597
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Intramemebrane protease 4; Presenilin-like protein 1; SPP-like 2B; SPPL2B; IMP4; KIAA1532; SPPL2b; PSL1; Signal peptide peptidase-like 2B isoform 3; Signal peptide peptidase-like 2B isoform 2
    Approved Symbol:

    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
    09743_3(10)
  • Isoform 2 : 8
  • Isoform 1 : 9
    • Additional Identifiers:

    HPRD: 09743 Entrez Gene ID: 56928 OMIM ID: 608239 Swissprot Accession: Q8TCT7;