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Description for Protein B2M

beta-2-microglobulin
19 total interacting proteins; 11 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 5/1)
(membrane: 2; platelet: 4)
Summary:
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia. (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • IGC: Immunoglobulin C-Type
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08055
    KEGG - Pathway(s):
    hsa04612
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    -
    Approved Symbol:
    B2M
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 3-Indolebutyric Acid(db);
  • N-Formylmethionine(db)

    Associated Genetic Diseases:

  • Hypoproteinemia, hypercatabolic(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00189 Entrez Gene ID: 567 OMIM ID: 109700 Swissprot Accession: P61769;